In spite of , ∨ Spite of Meaning, Definition & Usage

Definitions
  1. in opposition to all efforts of; in defiance or contempt of; notwithstanding. "Continuing, spite of pain, to use a knee after it had been slightly ibnjured." H. Spenser. "And saved me in spite of the world, the devil, and myself." South. "In spite of all applications, the patient grew worse every day." Arbuthnot. See Syn. under Notwithstanding.

Webster 1913